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CD4

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  • HY-P74300
    CD4 Protein, Rhesus Macaque (HEK293, Fc)

    T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4

    		 Rhesus Macaque HEK293
    CD4 Protein, an integral membrane glycoprotein, plays a pivotal role in immune responses. In T-cells, it serves as a coreceptor for MHC class II molecules, interacting with the T-cell receptor and initiating intracellular signaling pathways. In macrophages and NK cells, CD4 contributes to differentiation, cytokine expression, and cell migration independently of TCR/LCK. Additionally, CD4 is crucial in T-helper cell development, monocyte differentiation, and acts as the primary receptor for HIV-1, down-regulated by HIV-1 Vpu, and Human Herpesvirus 7/HHV-7. CD4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD4 Protein, Rhesus Macaque (HEK293, Fc) is 365 a.a., with molecular weight of ~67.4 kDa.
  • HY-P77616
    CD4 Protein, Rhesus Macaque (HEK293, His)

    CD4 antigen (p55); CD4 molecule; CD4 receptor; CD4; CD4mut; EU3

    		 Rhesus Macaque HEK293
    CD4 Protein forms surface dimers, interacts with LCK and PTK2/FAK1, and binds to P4HB/PDI. It induces CD4-dependent signaling with IL16. CD4 interacts with MHCII alpha and beta chains, increasing TCR affinity. Oligomerization of CD4 is necessary for stable MHCII binding and T cell-APC adhesion. CD4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD4 Protein, Rhesus Macaque (HEK293, His) is 365 a.a., with molecular weight of 45-52 kDa.

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